DECAMETHONIUM BROMIDE
Decamethylenebis(Trimethylammonium Bromide)
CAS: 541-22-0
Molecular Formula: C16H38Br2N2
DECAMETHONIUM BROMIDE - Names and Identifiers
| Name | Decamethylenebis(Trimethylammonium Bromide) |
| Synonyms | decacuran dekamethoniumbromid DECAMETHONIUM BROMIDE decamethoniumdibromide Decamethylenebis(Trimethylammonium Bromide) decamethylenebis(trimethyl-ammoniudibromide decamethylene-1,10-bistrimethylammoniumdibromide 10-decanediaminium,n,n,n,n',n',n'-hexamethyl-dibromide 1,10-Decanediaminium,N,N,N,N',N',N'-hexamethyl-,dibromide |
| CAS | 541-22-0 |
| EINECS | 208-772-2 |
DECAMETHONIUM BROMIDE - Physico-chemical Properties
| Molecular Formula | C16H38Br2N2 |
| Molar Mass | 418.29 |
| Melting Point | 263-267°C(lit.) |
| Water Solubility | almost transparency |
| Appearance | crystalline |
| Color | off-white |
| Maximum wavelength(λmax) | λ: 240 nm Amax: 0.04λ: 250 nm Amax: 0.03λ: 260 nm Amax: 0.02λ: 500 nm Amax: 0.02 |
| Merck | 14,2847 |
| BRN | 3728288 |
| Storage Condition | Inert atmosphere,Room Temperature |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| MDL | MFCD00011779 |
| Use | This product is for scientific research only and shall not be used for other purposes. |
| In vitro study | Decamethium (Syncurine), a depolarizing muscle relaxant or neuromuscular blocker, is used in anesthesia to induce paralysis. Decamethium, short acting, similar to acetylcholine, acts as a partial agonist of nicotinic acetylcholine receptors. In the motor neuromuscular endplate, it causes depolarization, prevents further action on the normal release of acetylcholine from the presynaptic terminal, and thus prevents nerve stimulation from affecting the muscle. During binding, decamethium actually activates (depolarizes) the motor endplate, but since decamethium itself does not degrade, the cell membrane remains depolarized and unresponsive to normal acetylcholine release. |
DECAMETHONIUM BROMIDE - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | R25 - Toxic if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | BP5950000 |
| FLUKA BRAND F CODES | 3-10 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
| Toxicity | LD50 oral in mouse: 190mg/kg |
DECAMETHONIUM BROMIDE - Reference Information
| biological activity | Decamethonium Bromide is a nicotinic AChR partial agonist and neuromuscular blocker. |
| target | TargetValue nAChR |
| Target | Value | in vitro study | Decamethonium (Syncurine) is a depolarizing muscle relaxant or neuromuscular blocker, which is used for anesthesia to induce paralysis. Decamethonium, the action time is short, similar to acetylcholine, as a partial agonist of nicotinic acetylcholine receptor. In the motor neuromuscular endplate, it causes depolarization, prevents further effects on the normal release of acetylcholine from the presynaptic endings, and thus prevents nerve stimulation from affecting the muscles. During the binding process, the decamethonium actually activates (depolarizes) the motor endplate, but since the decamethonium itself does not degrade, the cell membrane remains depolarized and does not respond to normal acetylcholine release. |
| category | toxic substances |
| toxicity classification | highly toxic |
| acute toxicity | abdominal cavity-rat LD50: 2.9 mg/kg; Oral administration-mouse LD50: 190 mg/kg |
| flammability hazard characteristics | flammability, the fire field discharges nitrogen oxides and bromide spicy and irritating smoke |
| storage and transportation characteristics | warehouse ventilation and low temperature drying; Separate storage and transportation with acids, oxidants, and food raw materials |
| fire extinguishing agent | sand, dry powder |
| EPA chemical information | The information is: offered by ofmpub.epa.gov (external link) |
Last Update：2024-04-09 20:52:54
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Product Name: Decamethylenebis(Trimethylammonium Bromide) Visit Supplier Webpage Request for quotationCAS: 541-22-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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